Development of polymeric micelles for targeting intractable cancers
نویسندگان
چکیده
منابع مشابه
Development of polymeric micelles for targeting intractable cancers
In relation to recent advances in nanobiotechnologies, cancer-targeted therapy using nano-scaled drug carriers (nanocarriers) has been attracting enormous attention with success in clinical studies. Polymeric micelles, core-shell-type nanoparticles formed through the self-assembly of block copolymers, are one of the most promising nanocarrier, because their critical features such as size, stabi...
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Polymeric micelles, which form upon self-assembly of amphiphilic macromolecules, can act as vehicles for the oral delivery of these drugs. This manuscript.This review summarizes recent developments related to targeted anticancer drug delivery to tumor sites using polymeric micelles via active and passive.approach in the field of polymeric drug delivery systems was introduced by the. Functionali...
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BACKGROUND Solid tumors need new blood vessels to feed and nourish them as well as to allow tumor cells to escape into the circulation and lodge in other organs, which is termed "angiogenesis." Some tumor cells within solid tumors can overexpress integrins α(v)β(3) and α(v)β(5), which can specifically recognize the peptide motif Arg-Gly-Asp (RGD). Thus, the targeting of RGD-modified micelles to...
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INTRODUCTION Amphiphilic copolymers are capable of forming core shell-like structures at the critical micellar concentration (CMC); hence, they can serve as drug carriers. Thus, in the present work, polymeric micelles based on novel chitosan derivative were synthesized. METHODS Block copolymer of palmitoyl glycol chitosan sulfate (PGCS) was prepared by grafting palmitoyl and sulfate groups se...
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ژورنال
عنوان ژورنال: Cancer Science
سال: 2016
ISSN: 1347-9032,1349-7006
DOI: 10.1111/cas.12960